Understanding the role of AKT-independent signaling downstream of PI3K is certainly important because: a) AKT isn’t always hyperactivated in the context of mutations in PI3K pathway components such as for example and that raise PIP3 amounts in cancer; b) many important cellular procedures are motivated by PI3K-dependent but AKT-independent signaling to market malignant phenotypes, and; c) systems of level of resistance to PI3K pathway inhibitors can involve the activation of PI3K-dependent signaling protein that can replacement for AKT signaling
OnUnderstanding the role of AKT-independent signaling downstream of PI3K is certainly important because: a) AKT isn’t always hyperactivated in the context of mutations in.
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